Serologic and virologic tests
- anti-HBs 跟 HBsAg 兩個只能有一個存在
- Precore mutant: HBeAg not made, but anti-HBe can develop due to → x-reactivity w/ HBcAg; a/w ↑ HBV DNA
- HBsAg: appears before sx; used to → screen blood donors; persists >6 mo = chronic HBV
- HBeAg: evidence of viral replication and ↑ infectivity
- IgM anti-HBc: 1st Ab to → appear; indicates acute infection window period = HBsAg becomes ⊖, anti-HBs not yet ⊕, anti-HBc only clue to → infxn
- IgG anti-HBc: indicates previous (HBsAg ⊖) or ongoing (HBsAg ⊕) HBV infection
- anti-HBe: indicates waning viral replication, ↓ infectivity
- anti-HBs: indicates resolution of acute disease & immunity (sole marker after vaccination)
- HBV DNA: presence in serum correlates w/ active viral replication in liver
see also 👉 Laboratory Abnormalities of HBV Clinical Presentation
→ 急性感染後恢復者: 感染 B 型肝炎病毒約半年後：HBsAg 消失、Anti-HBs 出現
- HBsAg + : 1.好肝帶原者; 2.壞肝 cHBV
- HBsAg - : 見下表 hint: 中過 = 中 = Core = Center
| HBsAg - | Anti-HBs + | Anti-HBs - |
|---|---|---|
| anti-HBc + | 中過、好了 | 中過、 沒免疫力 (危) |
| anti-HBc - | 打過疫苗 | 沒中過也沒抗體 |
if anti-HBc = TRUE: check(anti-HBe, HBeAg, HBV_DNA)